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The role of the BAFF/APRIL system on T cell function

โœ Scribed by Fabienne Mackay; Helen Leung


Book ID
116885463
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
215 KB
Volume
18
Category
Article
ISSN
1044-5323

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The role of APRIL and BAFF in lymphocyte
โœ Pascal Schneider ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 217 KB

The TNF family ligands BAFF (also called BLyS) and APRIL regulate lymphocyte survival and activation. BAFF binds to three receptors, BAFF-R, TACI and BCMA, whereas APRIL interacts with TACI, BCMA and proteoglycans. The contribution of BAFF and APRIL to B-cell and plasma-cell survival, CD154 (CD40L)-