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The Role of the 5'-Hydroxyl Group of Adenosine in Determining Substrate Specificity for Adenosine Deaminase

โœ Scribed by Bloch, Alexander.; Robins, Morris J.; McCarthy, James R.

Book ID
126202415
Publisher
American Chemical Society
Year
1967
Tongue
English
Weight
640 KB
Volume
10
Category
Article
ISSN
0022-2623

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AbstractรFrom adenosine 1, 2 H -deoxyadenosine 3 and 3 H -deoxyadenosine 5 all the acetates were prepared by lipase-catalyzed reactions. Only the acetates with free 5 H -hydroxy group were deaminated by adenosine deaminase (ADA), conยฎrming the crucial role of 5 H -OH for the enzyme activity.