✦ LIBER ✦

The role of stroma in immune recognition and destruction of well-established solid tumors

✍ Scribed by Ping Yu; Donald A Rowley; Yang-Xin Fu; Hans Schreiber

Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 134 KB
Volume: 18
Category: Article
ISSN: 0952-7915
DOI: 10.1016/j.coi.2006.01.004

No coin nor oath required. For personal study only.

✦ Synopsis

Well-established solid tumors (at least 14 days old and >1 cm in average diameter) are extremely difficult to eradicate immunologically in mice. Most cancer patients that seek medical attention bear primary or metastatic tumors that have grown for longer and that are larger than the tumors we call established. Therefore, focusing research on the problems of rejecting well-established mouse tumors might help in the development of novel concepts and protocols for destroying tumors in patients. A particular problem with established cancers is that even when treatments induce temporary regression, cancer often recurs. Recent studies suggest that manipulation of the stromal microenvironment of these tumors can induce immune recognition and regression. Furthermore, targeting cancer cells as well as tumor stroma for immune destruction might be needed to prevent recurrence.

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