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The Role of SPARC in Human Ulcerative Colitis and Murine Dextran Sodium Sulfate-Induced Colitis

✍ Scribed by Takagi, Tomohisa ;Naito, Yuji ;Aoi, Wataru ;Horie, Ryusuke ;Uchiyama, Kazuhiko ;Mizushima, Katsura ;Hirai, Yasuko ;Tsuji, Toshifumi ;Yoriki, Hiroyuki ;Kugai, Munehiro ;Fukumoto, Kohei ;Inoue, Ken ;Yamada, Shinya ;Harusato, Akihito ;Yoshida, Naohisa ;Katada, Kazuhiro ;Ishikawa, Takeshi ;Handa, Osamu ;Konishi, Hideyuki ;Wakabayashi, Naoki ;Yagi, Nobuaki ;Kokura, Satoshi ;Ichikawa, Hiroshi ;Yoshikawa, Toshikazu

Book ID: 123480313
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 44 KB
Volume: 140
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(11)63473-2

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## Background: In this study we determined the consequence of the absence of each tnf receptor, tnfr1 or tnfr2, in the dextran sulfate sodium (dss) model of colitis. ## Methods: Wildtype (wt), tnfr1(-/-) and tnfr2(-/-) mice were fed 3% w/v dss in drinking water for 5 days followed by 2 (day 7) or