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The role of receptor kinase in insulin action and the effects of insulin on human hepatoma cells

✍ Scribed by C.K. Chou

Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
542 KB
Volume
23
Category
Article
ISSN
0009-9120

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✦ Synopsis

Insulin has both short- and long-term effects on cellular metabolism. The short-term effects are known to involve the insulin receptor, a protein kinase capable of phosphorylating itself and other proteins. The role of the receptor was elucidated by studies of a mutant insulin receptor which lacked kinase activity and inhibited several actions of insulin. The long-term effects of insulin could be demonstrated by its growth-promoting effect on hepatoma cells, and by the suppression in transfected hepatoma cells of hepatitis B virus antigen production in a dose-dependent manner. The process whereby insulin appears to regulate gene expression is not clearly understood.

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