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The role of reactive oxygen species in silicon dioxide nanoparticle-induced cytotoxicity and DNA damage in HaCaT cells

✍ Scribed by Chunmei Gong; Gonghua Tao; Linqing Yang; Jianjun Liu; Haowei He; Zhixiong Zhuang

Publisher: Springer
Year: 2011
Tongue: English
Weight: 952 KB
Volume: 39
Category: Article
ISSN: 0301-4851
DOI: 10.1007/s11033-011-1287-z

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## Abstract Microglia are activated by lipopolysaccharide (LPS) to produce neurotoxic pro‐inflammatory factors and reactive oxygen species (ROS). While a multitude of LPS receptors and corresponding pathways have been identified, the detailed mechanisms mediating the microglial response to LPS are