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Stimulation of NADPH-dependent reactive oxygen species formation and DNA damage by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat peritoneal lavage cells

✍ Scribed by N. Z. Alsharif; W. J. Schlueter; S. J. Stohs

Publisher
Springer
Year
1994
Tongue
English
Weight
641 KB
Volume
26
Category
Article
ISSN
0090-4341

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✦ Synopsis

E n v i r o n m e n t a l C o n t a m i n a t i o n a n d T o x i c o l o g y

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## Abstract 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin (TCDD) was classified by the International Agency for Research on Cancer as a carcinogen in humans. It acts through an aryl hydrocarbon receptor‐mediated mechanism, inducing the transcription of numerous genes, including various cytochrome P450s (CYPs