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The role of protein-solvent interactions in protein unfolding

✍ Scribed by Celia A Schiffer; Volker Dötsch

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
527 KB
Volume
7
Category
Article
ISSN
0958-1669

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✦ Synopsis

Protein unfolding occurs when the balance of forces between the protein's interaction with itself and the protein's interaction with its environment is disrupted. The disruption of this balance of forces may be as simple as a perturbance of the normal water structure around the protein. A decrease in the normal water-water interaction will result in an increase in the relative interaction of water with the protein. An increase in the number of interactions between water and the protein may initiate a protein's unfolding. This model for protein unfolding is supported by a range of recent experimental and computational data.

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✍ Shin-Ichi Segawa; Mitsuru Sugihara 📂 Article 📅 2007 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 886 KB

The influence of proline cis-trans isomerization on the kinetics of lysozyme unfolding was examined carefully according to the theory of Hagerman and Baldwin "1976) Biochemistry 15, 1462-14731. As a result, the kinetics of lysozyme unfolding was found to follow the two-state transition model well. T