The role of protein kinase C in insulin biosynthesis
โ Scribed by D. J. Gwilliam; P. M. Jones; S. J. Persaud; S. L. Howell
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 754 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0940-5429
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Many extracellular signals elicit Ca2 + mobilization and diacylglycerol formation in their target cells. Diacylglycerol is derived from the receptor-linked phosphoinositide turnover and serves as a second messenger for the activation of protein kinase C in the presence of Ca2+ and phosphatidylserine
The role of protein kinase C in insulin signal transduction is controversial It has been postulated that protein kinase C is activated by insulin and that the kinase is directly involved in insulin-mediated metabolic processes In opposition to this view is the hypothesis that protein kinase C is not
Phorbol 12-myristate 13-acetate (PMA) has been shown to stimulate DNA synthesis and cell proliferation in a population of glial cells isolated from newborn rat brain. The non-tumor promoter 4a-phorbol l2,13-didecanoate (4a-PDD), on the other hand, was without an effect. The cultures treated with PMA