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The role of pharmacokinetics in determining the response of rodent embryos to teratogens in whole-embryo culture

โœ Scribed by Shum, L.; Warner, C.W.; Smith, M.Kate; Sadler, T.W.


Book ID
122807088
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
443 KB
Volume
2
Category
Article
ISSN
0887-2333

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An in vivo-in vitro test system with high sensitivity to teratogens has been developed and validated. A single acute intra-peritoneal injection of teratogens (1 8) and non-teratogens (13) was administered to pregnant rats on the 12th day after fertilisation, and uteri were removed after 16 h by lapa