✦ LIBER ✦

The role of PGP9.5 as a tumor suppressor gene in human cancer

✍ Scribed by Yutaka Tokumaru; Keishi Yamashita; Myoung Sook Kim; Hannah L. Park; Motonobu Osada; Masaki Mori; David Sidransky

Publisher: John Wiley and Sons
Year: 2008
Tongue: French
Weight: 386 KB
Volume: 123
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.23354

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

PGP9.5 is a controversial molecule from an oncologic point of view. We recently identified frequent methylation of PGP9.5 gene exclusively in primary head and neck squamous cell carcinoma (HNSCC), suggesting that it could be a tumor suppressor gene. On the other hand, PGP9.5 was reported to be overexpressed in a subset of human cancers presumably due to intrinsic oncogenic properties or as a result of transformation. To demonstrate that PGP9.5 possesses tumor suppressive activity, we examined forced expression by stable transfection of PGP9.5 in 4 HNSCC cell lines. Although all 4 cell lines demonstrated reduced log growth rates in culture after transfection, only 2 cell lines with wild type p53 (011, 022) demonstrated decreased growth in soft agar. In 2 cell lines with mutant p53 (013, 019), we observed no altered growth in soft agar and increased sensitivity to UV irradiation. We then tested for and found a high frequency of promoter methylation in a larger panel of primary tumors including HNSCC, esophageal SCC, gastric, lung, prostate and hepatocellular carcinoma. Our data support the notion that PGP9.5 is a tumor suppressor gene that is inactivated by promoter methylation or gene deletion in several types of human cancers. © 2008 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Characterization of C4-2 as a tumor-supp

Characterization of C4-2 as a tumor-suppressor gene in human brain tumors

✍ Sehgal, Anil; Keener, Cassie; Boynton, Alton L.; Young, Ronald F.; Vermeulen, Sa 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 189 KB 👁 3 views

Background: Brain tumors claimed the lives of 13,300 people in 1995. Our objective was to isolate and characterize unique tumor-suppressor genes from human brain tumors derived from patients in the United States. Methods: Differential display-polymerase chain reaction was used to isolate tumor suppr

Human pHyde is not a classical tumor sup

Human pHyde is not a classical tumor suppressor gene in prostate cancer

✍ Kati P. Porkka; Nina N. Nupponen; Teuvo L.J. Tammela; Robert L. Vessella; Tapio 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 180 KB 👁 1 views

## Abstract A novel putative tumor suppressor gene, __pHyde__, was recently cloned from rat prostate. The rat gene has been shown to inhibit prostate cancer cell proliferation both __in vitro__ and __in vivo__. However, the role of human __pHyde__ in prostate cancer has not been studied before. Her

Identification of Fat4 as a candidate tu

Identification of Fat4 as a candidate tumor suppressor gene in breast cancers

✍ Chao Qi; Yiwei Tony Zhu; Liping Hu; Yi-Jun Zhu 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 382 KB 👁 3 views

## Abstract __Fat__, a candidate tumor suppressor in __Drosophila__, is a component of Hippo signaling pathway involved in controlling organ size. We found that a ∼3 Mbp deletion in mouse chromosome 3 caused tumorigenesis of a non‐tumorigenic mammary epithelial cell line. The expression of __Fat4__

Silencing of the PTEN tumor-suppressor g

Silencing of the PTEN tumor-suppressor gene in anaplastic thyroid cancer

✍ Tony Frisk; Theodoris Foukakis; Trisha Dwight; Jonas Lundberg; Anders Höög; Göra 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 189 KB 👁 2 views

## Abstract Germline mutations in the tumor‐suppressor gene __PTEN__ (__MMAC1, TEP1__) are found in Cowden syndrome, which predisposes to hamartomas, breast cancer, trichilemmomas, and thyroid tumors of follicular epithelium. __PTEN__ has also been found to be somatically deleted, mutated, and/or s

High frequency of deletion on chromosome

High frequency of deletion on chromosome 9p21 may harbor several tumor-suppressor genes in human prostate cancer

✍ Geetha Perinchery; Nikola Bukurov; Koichi Nakajima; James Chang; Long-Cheng Li; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 293 KB 👁 1 views

Chromosome 9p has been reported to be a critical region of loss in various cancers. Our present study was designed to determine the frequency of deletions at different loci of chromosome 9p in microdissected samples of normal prostatic epithelium and carcinoma from the same patients. For this purpos

Pharmacogenomics of the p53 tumor suppre

Pharmacogenomics of the p53 tumor suppressor and its role in cancer chemoresistance

✍ Suxing Liu; W. Robert Bishop; Bimal Dasmahapatra; Yaolin Wang 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 214 KB 👁 1 views

## Abstract Drug resistance remains a key obstacle to successful cancer treatment. The implementation of pharmacogenomics is widely proclaimed as a route to revolutionize the face of cancer therapy. Here we discuss the pharmacogenomics of the p53 tumor suppressor and its role in cancer chemosensiti