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The role of PAK-1 in activation of MAP kinase cascade and oncogenic transformation by Akt

✍ Scribed by Somanath, P R; Vijai, J; Kichina, J V; Byzova, T; Kandel, E S


Book ID
109970912
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
228 KB
Volume
28
Category
Article
ISSN
0950-9232

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## Abstract Many G protein coupled receptors (GPCRs) cause phosphorylation of MAP kinases through transactivation of the epidermal growth factor receptor (EGF‐R), leading to increased cell survival and growth, motility, and migration. Phosphoinositide 3‐kinase (PI3K) is one of the important cell su