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Downregulation of c-fos gene transcription in cells transformed by E1A and cHa-ras oncogenes: a role of sustained activation of MAP/ERK kinase cascade and of inactive chromatin structure at c-fos promoter

✍ Scribed by Kukushkin, Alexander N; Abramova, Maria V; Svetlikova, Svetlana B; Darieva, Zalfia A; Pospelova, Tatiana V; Pospelov, Valery A


Book ID
110066338
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
346 KB
Volume
21
Category
Article
ISSN
0950-9232

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## Abstract We have previously shown that transcription of immediate‐early __c‐fos__ protooncogene is becoming strongly repressed in rat embryo fibroblasts transformed by oncogenes __E1A__ and __cHa‐ras__, so that serum only slightly stimulated __c‐fos__ transcription in these cells in contrast to