The role of p53 in pigmentation, tanning and melanoma
β Scribed by Neil F. Box; Tamara Terzian
- Book ID
- 118074621
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2008
- Tongue
- English
- Weight
- 437 KB
- Volume
- 21
- Category
- Article
- ISSN
- 1755-1471
No coin nor oath required. For personal study only.
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Alterations of the p53 tumor suppressor gene are the most frequent genetic abnormalities in human malignancies, but the role of p53 in the etiology of malignant melanomas is unclear. Fifty unselected malignant melanomas were analyzed for p53 overexpression by immunohistochemistry using 3 monoclonal
## Abstract The abrogation of the function of the βgatekeeper of the genomeβ, p53, is the most prevalent molecular alteration in solid human tumors. Regarding melanomas the involvement of __p53__ alterations is discussed controversially to date. In order to evaluate the status of p53 in detail, pri