The role of p53 in chemosensitivity and radiosensitivity
β Scribed by El-Deiry, Wafik S
- Book ID
- 110068035
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 167 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0950-9232
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## BACKGROUND. Although p53 gene mutation frequently is observed in ovarian carcinoma, the function of the p53 gene in chemosensitivity has not been defined conclusively. The objective of the current study was to elucidate the relation between chemotherapy-induced apoptosis through the p53 pathway
## Abstract Histone deacetylases inhibitors (HDIs) induce growth arrest and apoptosis in a variety of human cancer cells. Sodium butyrate (NaB), a histone deacetylase inhibitor, has been shown to cause a G~1~ cell cycle arrest by inducing p21^WAF1/CIP1^ in a __p53__βindependent manner. In this repo