𝔖 Bobbio Scriptorium
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The role of Notch in tumorigenesis: oncogene or tumour suppressor?

✍ Scribed by Radtke, Freddy; Raj, Kenneth

Book ID
109947026
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
430 KB
Volume
3
Category
Article
ISSN
1474-1776

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Pim genes were originally identified as oncogenes in mouse models in the 1980s, and were found to encode serine/threonine kinases with a broad range of cellular targets. Pim kinases have unique structural properties, and are characterized by a constitutive serine/threonine kinase activity that does