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For better or for worse: the role of Pim oncogenes in tumorigenesis

✍ Scribed by Nawijn, Martijn C.; Alendar, Andrej; Berns, Anton

Book ID
109948670
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
499 KB
Volume
11
Category
Article
ISSN
1474-1776

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For better or for worse: the role of Pim
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Pim genes were originally identified as oncogenes in mouse models in the 1980s, and were found to encode serine/threonine kinases with a broad range of cellular targets. Pim kinases have unique structural properties, and are characterized by a constitutive serine/threonine kinase activity that does

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