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The role of M1 muscarinic receptor agonism ofN-desmethylclozapine in the unique clinical effects of clozapine

✍ Scribed by D. M. Weiner; H. Y. Meltzer; I. Veinbergs; E. M. Donohue; T. A. Spalding; T. T. Smith; N. Mohell; S. C. Harvey; J. Lameh; N. Nash; K. E. Vanover; R. Olsson; K. Jayathilake; M. Lee; A. I. Levey; U. Hacksell; E. S. Burstein; R. E. Davis; M. R. Brann


Publisher
Springer
Year
2004
Tongue
English
Weight
267 KB
Volume
177
Category
Article
ISSN
0033-3158

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## Abstract Alterations in muscarinic M1 receptor protein and mRNA expression have been revealed in post‐mortem brains of schizophrenia patients. Most patients had been treated with antipsychotics, so medication effects cannot be excluded as a possible explanation for these results. With in situ hy