𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The role of Jak3 in lymphoid development, activation, and signaling

✍ Scribed by Daniel C Thomis; Leslie J Berg

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
698 KB
Volume
9
Category
Article
ISSN
0952-7915

No coin nor oath required. For personal study only.

✦ Synopsis

Mutations in a number of lymphoid signaling molecules lead to immunodeficiencies in mice and humans. Among these, one very pleiotropic syndrome results from deficiencies in an array of cytokine signaling pathways utilizing a cytokine receptor common y chain, Yo and the tyrosine kinase Jak3. Recent advances in our understanding of the role of Yc and Jak3 in lymphocyte development and function highlight the importance of cytokine receptor signaling pathways in regulating lymphoid homeostasis and responsiveness.

πŸ“œ SIMILAR VOLUMES

Revisiting the role of retinoid signalin
Revisiting the role of retinoid signaling in skeletal development
✍ Andrea D. Weston; Lisa M. Hoffman; T. Michael Underhill πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 787 KB

## Abstract Several years ago, it was discovered that an imbalance of vitamin A during embryonic development has dramatic teratogenic effects. These effects have since been attributed to vitamin A's most active metabolite, retinoic acid (RA), which itself profoundly influences the development of mu

Role of Btk in B cell development and si
Role of Btk in B cell development and signaling
✍ Stephen Desiderio πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 669 KB

Bruton's tyrosine kinase (Btk), the target of inactivating mutations in X-linked immunodeficiency diseases of mice and humans, is essential for normal B cell responsiveness. Recent studies have outlined a mechanism for the activation of Btk by B cell receptor engagement and have identified proximal

Cooperative and indispensable roles of e
Cooperative and indispensable roles of endothelin 3 and KIT signalings in melanocyte development
✍ Hitomi Aoki; Tsutomu Motohashi; Naoko Yoshimura; Hidetoshi Yamazaki; Toshiyuki Y πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 832 KB

## Abstract The development of melanocytes from neural crest‐derived precursor cells depends on signaling by the receptor tyrosine kinase KIT and the G protein‐coupled endothelin receptor B (EDNRB) pathways. Loss‐of‐function mutations in either of these two signaling receptor molecules cause a loss