Memory T cell responses are frequently highly restricted in terms of receptor usage. How and when such clonotypic dominance is established remains poorly understood. Here we have investigated the evolution of the T cell responses to an epitope from Epstein-Barr virus (EBV), (FLRGRAYGL), by analyzing
The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells
β Scribed by Simmi Mahajan; Ana Cervera; Megan MacLeod; Simon Fillatreau; Georgia Perona-Wright; Stephen Meek; Andrew Smith; Andrew MacDonald; David Gray
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 450 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0014-2980
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Cytotoxic T lymphocyte (CTL or CD8) responses are a major branch of the immune system involved in controlling viral infections. Murine models have shown that the development of effective and sustained CD8 cell responses requires CD4 T cell help. However, the precise mechanism in which CD4 cells prov