✦ LIBER ✦

The clonality of CD3+ CD10+ T cells in angioimmunoblastic T cell lymphoma, B cell lymphoma, and reactive lymphoid hyperplasia

✍ Scribed by Da Zhang; Carol J. Saunders; Weiwei Zhao; Mark Davis; Mark T. Cunningham

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 726 KB
Volume: 84
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.21483

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✦ Synopsis

T cells coexpressing CD3 and CD10 are a characteristic feature of angioimmunoblastic T-cell lymphoma (AITL) [1]. However, they are not unique to AITL, as these cells are also present in B cell lymphoma and reactive lymphoid hyperplasia [2]. To determine the significance of CD3+ CD10+ T cells, we used flow cytometry with cell sorting and molecular biology techniques for T cell gene rearrangement to study T cells from patients with AITL, B cell lymphoma, and reactive lymph node hyperplasia. We found that CD3+ CD10+ T cells in B cell lymphoma and reactive lymphoid hyperplasia were polyclonal. In early stage of AITL, they were oligoclonal, and became monoclonal as AITL progressed. These findings illustrate the differences between early and late lymphoma and could be important for the diagnosis of AITL.

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