✦ LIBER ✦

Follicular lymphoma B cells induce the conversion of conventional CD4+ T cells to T-regulatory cells

✍ Scribed by Weiyun Z. Ai; Jing-Zhou Hou; Robert Zeiser; Debra Czerwinski; Robert S. Negrin; Ronald Levy

Publisher: John Wiley and Sons
Year: 2009
Tongue: French
Weight: 288 KB
Volume: 124
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.23881

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

There has been accumulating evidence that CD4^+^CD25^+^ FoxP3 expressing regulatory T cells (Treg) are highly concentrated in tumors, thereby fostering an immune‐privileged microenvironment. Some studies have shown that T‐cell receptor (TCR) stimulation can convert conventional T cells into Treg. Follicular lymphoma (FL) B cells can enhance this Treg conversion. We investigated whether FL tumor B cells, as opposed to normal B cells, are unique in their ability to convert effector T cells into Treg. We found that tumor B cells alone, without artificial TCR stimulation, could induce conventional T cells to express FoxP3 and to acquire regulatory function. In contrast to their malignant counterpart, normal B cells did not induce Treg conversion. Treg conversion was independent of the T cell background, as T cells isolated from FL or normal peripheral blood were equally susceptible to being converted by tumor B cells. Our study provides evidence for a tumor‐specific mechanism by which FL tumor cells promote immune escape through the induction of Treg. © 2008 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

The clonality of CD3+ CD10+ T cells in a

The clonality of CD3+ CD10+ T cells in angioimmunoblastic T cell lymphoma, B cell lymphoma, and reactive lymphoid hyperplasia

✍ Da Zhang; Carol J. Saunders; Weiwei Zhao; Mark Davis; Mark T. Cunningham 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 726 KB

T cells coexpressing CD3 and CD10 are a characteristic feature of angioimmunoblastic T-cell lymphoma (AITL) [1]. However, they are not unique to AITL, as these cells are also present in B cell lymphoma and reactive lymphoid hyperplasia [2]. To determine the significance of CD3+ CD10+ T cells, we use

Sub-optimal CD4+ T-cell activation trigg

Sub-optimal CD4+ T-cell activation triggers autonomous TGF-β-dependent conversion to Foxp3+ regulatory T cells

✍ Vanessa G. Oliveira; Marta Caridade; Ricardo S. Paiva; Jocelyne Demengeot; Luis 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 288 KB

T-cell tolerance induced by repeated ant

T-cell tolerance induced by repeated antigen stimulation: Selective loss of Foxp3− conventional CD4 T cells and induction of CD4 T-cell anergy

✍ Lena Eroukhmanoff; Cecilia Oderup; Fredrik Ivars 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 223 KB 👁 1 views

Correction: T-cell tolerance induced by

Correction: T-cell tolerance induced by repeated antigen stimulation: Selective loss of Foxp3− conventional CD4 T cells and induction of CD4 T-cell anergy

✍ Lena Eroukhmanoff; Cecilia Oderup; Fredrik Ivars 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 47 KB 👁 1 views

Forced overexpression of either of the t

Forced overexpression of either of the two common human Foxp3 isoforms can induce regulatory T cells from CD4+CD25– cells

✍ Tineke Aarts-Riemens; Maarten E. Emmelot; Leo F. Verdonck; Tuna Mutis 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 460 KB 👁 1 views

Induced tolerance to rat liver allograft

Induced tolerance to rat liver allografts involves the apoptosis of intragraft T cells and the generation of CD4+CD25+FoxP3+ T regulatory cells

✍ Masato Fujiki; Carlos O. Esquivel; Olivia M. Martinez; Samuel Strober; Shinji Ue 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 403 KB

Posttransplant total lymphoid irradiation is a nonmyeloablative regimen that has been extensively studied in rodent models for the induction of tolerance to bone marrow and solid organ allografts. Previous studies of experimental models and clinical transplantation have used total lymphoid irradiati