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The role of histidine in the gastrointestinal hormone secretin

✍ Scribed by D. Voskamp; P. Kranenburg; H. C. Beyerman

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
457 KB
Volume
101
Category
Article
ISSN
0165-0513

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✦ Synopsis

Abstract

Eleven analogues of porcine gut secretin, in which the N‐terminal histidine has been modified or deleted, were prepared and assayed for their potency in stimulating the exocrine pancreatic flow in various animal species. Deletion of the α‐amino group, or replacement of the imidazole by the pyrazole ring, resulted in highly potent analogues. Other alterations destroyed most of the potency. All analogues had immunochemical properties similar to those of porcine gut secretin.

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Synthesis of the Gastrointestinal Peptid
Synthesis of the Gastrointestinal Peptide Hormone Secretin by the Repetitive Excess Mixed Anhydride (REMA) Method
✍ Arie van Zon; Hugo Christiaan Beyerman πŸ“‚ Article πŸ“… 1976 πŸ› John Wiley and Sons 🌐 German βš– 831 KB

## Abstract The REMA method was found to be very suitable for the synthesis of secretin. The procedure was rapid, since on a 0.2 mmol‐scale the rate of one amino acid per day could be attained, and yielded an unambiguous product after simple ion‐exchange chromatography. REMA‐secretin was found to b