Liver biopsy samples from 40 chronic alcoholic patients, including 9 with minimal changes of the liver, 6 with mild hepatic fibrosis, 14 with moderate fibrosis, and 11 with severe fibrosis (cirrhosis) were studied by electron microscopy to assess fibrogenesis in the Disse space and the role of fat-s
The role of hepatic fat-storing (stellate) cells in retinoid metabolism
β Scribed by Henk F. J. Hendriks; Adriaan Brouwer; Professor Dr. Dick L. Knook
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 556 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
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Fat-storing cells (perisinusoidal stellate cells) were isolated by enzymatic digestion of rat liver and purified by a single-step Nycodenz@ gradient to yield 11.4.10' cells per liver, with a purity of 74% and a viability of 76%. Monolayer cultures of fat-storing cells incorporated both [3SS]sulfate
## Abstract Retinoid derivatives are potent regulators of a wide variety of cellular functions through the modulation of nuclear receptor activity. Three distinct families of retinoid receptors have been identified so far, namely retinoic acid receptors, retinoic acid X receptors, and retinoic acid
Platelet-derived growth factor (PDGF) is the most potent mitogen for hepatic stellate cells (HSCs) in vitro. The aim of this study was to investigate the role of the lipid-derived second messenger phosphatidic acid (PA) in mediating this effect and, in particular, to determine its interaction with t
Cultured hepatic stellate cells were induced to elongate long, multipolar cellular processes by interstitial collagen gel used as a substratum, as compared to flattened or round cell shapes on polystyrene surface or on Matrigel containing the basement membrane components, respectively. The process i
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