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The role of glutathione detoxification pathway in MCLR-induced hepatotoxicity in SD rats

✍ Scribed by Li, Shangchun; Chen, Jun; Xie, Ping; Guo, Xiaochun; Fan, Huihui; Yu, Dezhao; Zeng, Cheng; Chen, Liang

Book ID
126486183
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
760 KB
Volume
30
Category
Article
ISSN
1520-4081

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## Abstract __p__‐Aminophenol (PAP) is a widely used industrial chemical and a known nephrotoxin. Recently, it was found to also cause hepatotoxicity and glutathione (GSH) depletion in mice. The exact mechanism of liver toxicity is not known. The aims of this study were to determine whether PAP can