The role of infliximab on paracetamol-induced hepatotoxicity in rats
โ Scribed by Ferah, Irmak; Halici, Zekai; Bayir, Yasin; Demirci, Elif; Unal, Bunyami; Cadirci, Elif
- Book ID
- 120201075
- Publisher
- Informa plc
- Year
- 2013
- Tongue
- English
- Weight
- 650 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0892-3973
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Research into the pathogenesis of acetaminophen (paracetamo1)-induced hepatotoxicity has concentrated on the generation of toxic metabolites by the hepatocytes. It has, however, recently been shown that human macrophages cultured with acetaminophen secrete increased quantities of tumour necrosis fac
The extracts of Swertia chirata were evaluated for antihepatotoxic activity using paracetamol and galactosamine models. The methanol extract of the whole plant was found active at a dose of 100 mg/kg i.p. On fractionating this extract into chloroform soluble and butanol soluble fractions, the activi