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The role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis

✍ Scribed by Raquel Domingo-Fernandez, Karen Watters, Olga Piskareva, Raymond L. Stallings, Isabella Bray

Book ID
118783494
Publisher
Springer-Verlag
Year
2012
Tongue
English
Weight
658 KB
Volume
29
Category
Article
ISSN
0179-0358

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## Summary Despite increasing understanding of its pathophysiology, the aetiology of systemic mast cell activation disease (MCAD) remains largely unknown. Research has shown that somatic mutations in kinases are necessary for the establishment of a clonal mast cell population, in particular mutatio