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Systemic mast cell activation disease: the role of molecular genetic alterations in pathogenesis, heritability and diagnostics

✍ Scribed by Britta Haenisch; Markus M. Nöthen; Gerhard J. Molderings

Book ID
117947205
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
207 KB
Volume
137
Category
Article
ISSN
0019-2805

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Systemic mast cell activation disease: t
Systemic mast cell activation disease: the role of molecular genetic alterations in pathogenesis, heritability and diagnostics
✍ Britta Haenisch; Markus M. Nöthen; Gerhard J. Molderings 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 207 KB

## Summary Despite increasing understanding of its pathophysiology, the aetiology of systemic mast cell activation disease (MCAD) remains largely unknown. Research has shown that somatic mutations in kinases are necessary for the establishment of a clonal mast cell population, in particular mutatio