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The role of Fe2+-induced lipid peroxidation in the initiation of the mitochondrial permeability transition

โœ Scribed by Vladimir Gogvadze; Patrick B Walter; Bruce N Ames

Book ID
117042436
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
133 KB
Volume
414
Category
Article
ISSN
0003-9861

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The role of iron in the initiation of li
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โœ Giorgio Minotti; Steven D. Aust ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 952 KB

Iron is required for the initiation of lipid peroxidation. Evidence is presented that lipid peroxidation requires both Fe 3รท and Fe aรท, perhaps with oxygen to form a Fe3+-dioxygen-Fe 2รท complex. Other mechanisms of initiation, mostly involving the iron-catalyzed formation of hydroxyl radical, axe de