The role of eosinophils in the pathogenesis of asthma
โ Scribed by Maria-Cristina Seminario; Gerald J. Gleich
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 661 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0952-7915
No coin nor oath required. For personal study only.
โฆ Synopsis
The eosinophil is regarded as a key mediator of the pathology and abnormal physiology of bronchial asthma. Current investigations are directed at understanding how eosinophils are attracted into the respiratory tract and how they bring about the abnormalities characteristic of this disease.
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An association between eosinophilia and neutropenia has been observed in a number of clinical conditions. To probe the role of eosinophils in granulopoiesis, marrow and peritoneal eosinophils, obtained from Schbrosoma munsoni-infected mice, were separated and purified. Normal bone marrow cells were
## Abstract Asthma is a chronic disorder of the airways characterized by variable airway narrowing, mucus hypersecretion, and infiltration of the airway wall with eosinophils. It is now believed that asthma is controlled by Th2 lymphocytes producing cytokines such as ILโ4, ILโ5, ILโ9, and ILโ13. An