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The role of eosinophil in regulation of granulopoiesis

✍ Scribed by Renee V. Gardner; Cameron K. Tebbi; David Chervinsky; Michael McGarry

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
557 KB
Volume
4
Category
Article
ISSN
0278-0232

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✦ Synopsis

An association between eosinophilia and neutropenia has been observed in a number of clinical conditions. To probe the role of eosinophils in granulopoiesis, marrow and peritoneal eosinophils, obtained from Schbrosoma munsoni-infected mice, were separated and purified. Normal bone marrow cells were cultured in semisolid culture medium in concentrations ranging from 5 x lo4 to 5 x lo5, with and without added eosinophils.

To examine whether high prostaglandin E (PGE) content of eosinophils affects granulopoiesis, idomethacin was added to duplicate marrow cultures containing eosinophils. The addition of eosinophils to normal syngeneic marrow culture caused a significant inhibition of granuloyte-macrophage colony formation (CFU-GM) in culture. This suppressive effect was reversible upon addition of indomethacin. These findings suggest that eosinophils, in vitro, are capable of inhibition of granulopoiesis. The reversal of this effect by indomethacin indicates that this suppression may be prostaglandin mediated.

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