## Abstract In the present study, DNA flow cytometry (FCM) and immunocytochemistry (ICC) with a selected panel of antibodies were performed on 51 cases of malignant tumors which were referred for fineβneedle aspiration biopsy (FNAB) to our Department of Cytology for the last 2 yr. Twelve cases were
The role of DNA flow cytometry in borderline malignant ovarian tumors
β Scribed by Chyong-Huey Lai; Swei Hsueh; Ting-Chang Chang; Chih-Jen Tseng; Kuan-Gen Huang; Hung-Hsueh Chou; Shiow-Meei Chen
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 923 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0008-543X
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β¦ Synopsis
BACKGROUND.
The role of flow cytometric DNA analysis in predicting prognosis of patients with borderline malignant ovarian tumors has been controversial.
METHODS.
Fifty cases of patients with borderline malignant ovarian tumors were analyzed by histology and by flow cytometry on paraffin embedded tissue. Multiple tissue blocks and serial sections were analyzed for each tumor. The results of DNA analysis were correlated to clinicopathologic data.
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In a prospective study, 112 fresh ovarian tumor samples were collected from 83 consecutive patients. Cellular DNA content was measured by flow cytometry. All the benign (n = 24) and semimalignant (n = 6) tumors were diploid. Of 50 malignant tumors, 24 (48%) were diploid and 26 (52%) were aneuploid.