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The role of cytochrome P450 2C3 in rabbit liver microsomal metabolism of 1-nitropyrene and 3-nitrofluoranthene

✍ Scribed by Howard, Paul C. ;McManus, Michael E. ;Koop, Dennis R.

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 774 KB
Volume: 9
Category: Article
ISSN: 0887-2082
DOI: 10.1002/jbt.2570090204

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✦ Synopsis

The male rabbit liver microsomal cytochrome P450 metabolism of 1-nitropyrene and 3- nitrofluoranthene was investigated. In this study, we used inhibitory antibodies specific for rabbit P450 2C3 and determined that, in untreated male rabbit liver microsomes, the antibody inhibited approximately 75% of the cytochrome P450-mediated C-oxidation of both I-nitropyrene and 3nitrofluoranthene. These results verify our previous prediction that mainly one cytochrome P450 is responsible for microsomal metabolism of 1- nitropyrene in the untreated rabbit liver.

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