The Role of Cystine-Glutamate Exchange in Nicotine Dependence in Rats and Humans
โ Scribed by Lori A. Knackstedt; Steven LaRowe; Pascale Mardikian; Robert Malcolm; Himanshu Upadhyaya; Sarra Hedden; Athina Markou; Peter W. Kalivas
- Book ID
- 119198087
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 541 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0006-3223
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The system x 2 C (Sx 2 C ) transporter functions to mediate the exchange of extracellular cystine (L-Cys 2 ) and intracellular glutamate (L-Glu). Internalized L-Cys 2 serves as a ratelimiting precursor for the biosynthesis of glutathione (GSH), while the externalized L-Glu can contribute to either e