Expression and Developmental Regulation of the Cystine/Glutamate Exchanger (xc−) in the Rat
✍ Scribed by Vincenzo La Bella; Francesca Valentino; Tommaso Piccoli; Federico Piccoli
- Book ID
- 106483629
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 315 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0364-3190
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📜 SIMILAR VOLUMES
The system x 2 C (Sx 2 C ) transporter functions to mediate the exchange of extracellular cystine (L-Cys 2 ) and intracellular glutamate (L-Glu). Internalized L-Cys 2 serves as a ratelimiting precursor for the biosynthesis of glutathione (GSH), while the externalized L-Glu can contribute to either e
## Abstract The purpose of the present study was to elucidate the expression and regulation of the L‐cystine transporter, system x~c~^−^, in Müller cells. In this study, newly developed conditionally immortalized rat Müller cell lines (TR‐MUL) from transgenic rats harboring the temperature‐sensitiv
## Abstract Glutamate is the major excitatory transmitter in the CNS and plays distinct roles in a number of developmental events. Its extracellular concentration, which mediates these activities, is regulated by glutamate transporters in glial cells and neurons. In the present study, we have used