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The role of Crk/Dock180/Rac1 pathway in the malignant behavior of human ovarian cancer cell SKOV3

✍ Scribed by Hui Wang; Hua Linghu; Jin Wang; Ya-ling Che; Ting-xiu Xiang; Wei-xue Tang; Zhen-wei Yao


Book ID
107693776
Publisher
S. Karger AG
Year
2009
Tongue
English
Weight
290 KB
Volume
31
Category
Article
ISSN
1010-4283

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## Abstract BRCA1 is a multifunctional tumor‐suppressive protein. Many functional aspects of BRCA1 are not fully understood. We used a shRNA approach to probe the function of BRCA1 in human breast cancer cells. Knocking down BRCA1 expression by shRNA in the wild‐type BRCA1 human breast cancer MCF‐7