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The role of Chk1 signaling pathways in response to the topoisomerase I poison SN-38


Book ID
117659785
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
157 KB
Volume
38
Category
Article
ISSN
0959-8049

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The protein kinase Chk1 is essential for the DNA damage checkpoint. Cells lacking Chk1 are hypersensitive to DNA-damaging agents such as UV light and -irradiation because they fail to arrest the cell cycle when DNA damage is generated. Phosphorylation of Chk1 occurs after DNA damage and is dependent