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The role of poly(ADP-ribose) polymerase-1 (PARP-1) in the cellular response to topoisomerase I poisons


Book ID
117659558
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
129 KB
Volume
38
Category
Article
ISSN
0959-8049

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## Abstract We investigated the physical association of the DNA topoisomerase IIβ binding protein 1 (TopBP1), involved in DNA replication and repair but also in regulation of apoptosis, with poly(ADP‐ribose) polymerase‐1 (PARP‐1). This enzyme plays a crucial role in DNA repair and interacts with ma