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The role of CD8+ T-cell replicative senescence in human aging

โœ Scribed by Rita B. Effros; Mirabelle Dagarag; Carolyn Spaulding; Janice Man

Book ID
110746600
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
133 KB
Volume
205
Category
Article
ISSN
0105-2896

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CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta