✦ LIBER ✦

The role of CD1 molecules in immune responses to infection

✍ Scribed by Juli K Maher; Mitchell Kronenberg

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 572 KB
Volume: 9
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(97)80095-7

No coin nor oath required. For personal study only.

✦ Synopsis

Recent work on CD1 molecules has demonstrated that human CDlb and a lipoglycan from mycobacteria that CDlb presents colocalize to late endosomes. Presentation of this lipoglycan by CDlb requires antigen uptake via the mannose receptor. CD8 + CDl-restricted T cells can decrease the load of intracellular mycobacteria by granule release. TCR-transgenic and CDl-deficient mice have provided insights into the role of CD1 in the T helper responses required for the clearance of some microorganisms.

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