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The role of carbonic anhydrase IX in hypoxia control in OSCC

✍ Scribed by Mario Pérez-Sayáns; Claudiu T. Supuran; Silvia Pastorekova; José Manuel Suárez-Peñaranda; Gayoso-Diz Pilar; Francisco Barros-Angueira; José Manuel Gándara-Rey; Abel García-García


Book ID
111255600
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
211 KB
Volume
42
Category
Article
ISSN
0904-2512

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In the present study, we investigated the role of the extracellular signal-regulated protein kinase (ERK) in regulation of the hypoxia marker, carbonic anhydrase IX (CAIX). U0126, a specific inhibitor of MEK1/2, downregulated CAIX expression induced by true hypoxia and cell density. CA9 promoter act