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Monoclonal antibodies generated in carbonic anhydrase IX-deficient mice recognize different domains of tumour-associated hypoxia-induced carbonic anhydrase IX

✍ Scribed by Miriam Zat'ovičová; Kvetoslava Tarábková; Eliška Švastová; Adriana Gibadulinová; Vojtech Mucha; Lýdia Jakubı&#x0301;čková; Zuzana Biesová; Monika Rafajová; Marta Ortova Gut; Seppo Parkkila; Anna-Kaisa Parkkila; Abdul Waheed; Willam S. Sly; Ivan Horak; Jaromı&#x0301;r Pastorek; Silvia Pastoreková

Book ID: 113716663
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 696 KB
Volume: 282
Category: Article
ISSN: 0022-1759
DOI: 10.1016/j.jim.2003.08.011

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## Abstract Carbonic anhydrase IX (CA IX) is frequently expressed in human carcinomas and absent from the corresponding normal tissues. Strong induction by tumor hypoxia predisposes CA IX to serve as a target for cancer diagnostics and therapy. Here we evaluated targeting properties and pharmacokin