The role of biotransformation in the genotoxicity of allylic compounds
โ Scribed by Erwin Eder; Klaus Dornbusch; Gudrun Fischer
- Publisher
- Springer-Verlag
- Year
- 1987
- Tongue
- English
- Weight
- 378 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0340-5761
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Objective: The nature of the enzyme(s) catalysing the biotransformation of lornoxicam to one of its major metabolites, 5'-hydroxy-lornoxicam, has been investigated in human liver microsomes. the reaction kinetics were characterised, the affinity of lornoxicam for three major human drug metabolis
Three-carbon chemicals (chlorinated and nonchlorinated, saturated and unsaturated, hydroxy-and 0x0-hydrocarbons) were assayed for genotoxicity . The sister chromatid exchange test in vitro served as the test system. Without S9 mix, the nonchlorinated solvents 1-propanol, 2-propanol, and 2-propanone
Twenty metallic compounds were assayed for their genotoxic mutagenic activity by the bioluminescence test restoration of the luminescence of dark mutant of the luminous bacterium Photobacterium fischeri). The activity of the metals was tested in a liquid medium as well as on a solid medium. K2Cr207,