✦ LIBER ✦

Detection of genotoxicity of metallic compounds by the bacterial bioluminescence test

✍ Scribed by Ulitzur, S. ;Barak, M.

Publisher: John Wiley and Sons
Year: 1988
Weight: 356 KB
Volume: 2
Category: Article
ISSN: 0884-3996
DOI: 10.1002/bio.1170020206

No coin nor oath required. For personal study only.

✦ Synopsis

Twenty metallic compounds were assayed for their genotoxic mutagenic activity by the bioluminescence test restoration of the luminescence of dark mutant of the luminous bacterium Photobacterium fischeri). The activity of the metals was tested in a liquid medium as well as on a solid medium. K2Cr207, MnCI2, Be&, KH2As04, ZnCI2 and Na2W04 showed strong activity in liquid medium while AgN03, Cd(OOCCH3I2, CoCI2, CuCI2, HgCI2, Na2Se03 and Pb(NO& were more active in the solid medium test. BaClz, Na2Mo04, NaAs02, NiS04, NanSe04, RbCI, and SnCI2 were not active in the bioluminescence test. The correlation between the genotoxic activity of the tested metallic compounds in the bioluminescence test and other bacterial tests for genotoxic agents as well as the correlation between these results and the carcinogenicity of these compounds is discussed.

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