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The role of aromatic residues in the hydrophobic core of the villin headpiece subdomain

✍ Scribed by Benjamin S. Frank; Didem Vardar; Deirdre A. Buckley; C. James McKnight

Book ID: 111753277
Publisher: Cold Spring Harbor Laboratory Press
Year: 2009
Tongue: English
Weight: 144 KB
Volume: 11
Category: Article
ISSN: 0961-8368
DOI: 10.1110/ps.22202

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## Abstract We have investigated the folding pathway of the 36‐residue villin headpiece subdomain (HP‐36) by action‐derived molecular dynamics simulations. The folding is initiated by hydrophobic collapse, after which the concurrent formation of full tertiary structure and α‐helical secondary struc