ADAM-mediated ectodomain shedding of HB-
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Shigeki Higashiyama; Daisuke Nanba
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Article
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2005
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Elsevier Science
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English
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All ligands of the epidermal growth factor receptor (EGFR) which has important roles in development and disease, are shed from the plasma membrane by metalloproteases. The ectodomain shedding of EGFR ligands has emerged as a critical component in the functional activation of EGFR in the interrecepto