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The role of ADAM-mediated shedding in vascular biology

โœ Scribed by Daniela Dreymueller; Jessica Pruessmeyer; Ester Groth; Andreas Ludwig


Book ID
113582941
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
930 KB
Volume
91
Category
Article
ISSN
0171-9335

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All ligands of the epidermal growth factor receptor (EGFR) which has important roles in development and disease, are shed from the plasma membrane by metalloproteases. The ectodomain shedding of EGFR ligands has emerged as a critical component in the functional activation of EGFR in the interrecepto