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Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17

โœ Scribed by Umut Sahin; Carl P. Blobel


Book ID
118442118
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
156 KB
Volume
581
Category
Article
ISSN
0014-5793

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All ligands of the epidermal growth factor receptor (EGFR) which has important roles in development and disease, are shed from the plasma membrane by metalloproteases. The ectodomain shedding of EGFR ligands has emerged as a critical component in the functional activation of EGFR in the interrecepto