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The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy

✍ Scribed by Victoria C. Foletta; Lloyd J. White; Amy E. Larsen; Bertrand Léger; Aaron P. Russell


Book ID
106110562
Publisher
Springer
Year
2011
Tongue
English
Weight
316 KB
Volume
461
Category
Article
ISSN
0031-6768

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Muscle wasting in catabolic patients is in part mediated by glucocorticoids and is associated with increased expression and activity of the transcription factor C/EBPb. It is not known, however, if C/EBPb is causally linked to glucocorticoid-induced muscle atrophy. We used dexamethasone-treated L6 m