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Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are up-regulated in aged rat Tibialis Anterior muscle

✍ Scribed by Stephan Clavel; Anne-Sophie Coldefy; Emilie Kurkdjian; Jérôme Salles; Irène Margaritis; Benoît Derijard


Book ID
113775985
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
288 KB
Volume
127
Category
Article
ISSN
0047-6374

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## Abstract Muscle wasting is commonly seen in patients with hyperthyroidism and is mainly caused by stimulated muscle proteolysis. Loss of muscle mass in several catabolic conditions is associated with increased expression of the muscle‐specific ubiquitin ligases atrogin‐1 and MuRF1 but it is not