The prognostic significance and nature of p53 dysfunction in ovarian carcinoma is unclear. The relation between p53 overexpression, p53 mutations, and their effects on overall survival in primary ovarian carcinoma is explored. ## METHODS. Tumor specimens from 171 consecutive epithelial ovarian ca
The role and prognostic significance of p53 gene alterations in breast cancer
โ Scribed by Richard M. Elledge; Suzanne A. W. Fuqua; Gary M. Clark; Pascal Pujol; D. Craig Allred
- Publisher
- Springer US
- Year
- 1993
- Tongue
- English
- Weight
- 694 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0167-6806
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## Abstract Overexpression of the nuclear phosphoprotein p53 is one of the most frequently detected abnormalities in human cancer and appears to be associated with mutation of the p53 gene. In this study of breast cancer, p53 overexpression was detected in two (15%) of 15 pure intraductal tumors, 7
The immunohistochemical expression of p53 and c-erbB-2 gene proteins was examined in a series of 130 breast adenocarcinomas. This study intended to investigate whether the frequency of the altered expression of the tumour suppressor gene p53 and the overexpression of the oncogene c-erbB-2 in breast